Gamma-linolenic acid

This synergy of organic evening primrose and borage oil is appreciated for its richness in gamma-linolenic acid. This polyunsaturated fatty acid of the omega-6 family has properties for the skin, hormonal balance and acts on the modulation of the immune system (autoimmune diseases). GLA, detailed in numerous scientific journals, promotes the synthesis of type 1 prostaglandins (anti-inflammatory) to the detriment of type 2 prostaglandins (pro-inflammatory). The anti-inflammatory actions are mainly recognised in hormonal disorders, such as premenstrual syndrome[1], menopausal discomfort[2], reduction of acne[3] and help in case of eczema[4]. GLA has been clinically studied in other inflammatory conditions such as osteoporosis[5] and in reducing the symptoms of rheumatoid arthritis with a daily GLA intake of 480mg (7 capsules)[6-7]. Finally, the administration of evening primrose and borage oils rich in gamma-linolenic acid to asthmatic patients inhibits the formation of pro-inflammatory leukotrienes [8-9].

Nutritional information

* Recommended Daily Allowance (Directive 2008/100/EC amending -> Decree 08.01.1992)

Studies

[1] Edilberto A Rocha Filho et al ; "Essential fatty acids for premenstrual syndrome and their effect on prolactin and total cholesterol : a randomised, double-blind, placebo-controlled study" ; Reproductive Health 2011, 8:2 doi : 10.1186/1742- 4755-8-2. 

[2] Farzaneh, F., Fatehi, S., et al. (2013) "The effect of oral evening primrose oil on menopausal hot flushes : a randomised clinical trial". 

[3] " L'efficacité et la sécurité de l'acide gamma-linolénique dans le traitement de l'acné vulgaire " ; Int J Dermatol. 2014 ; 53(3) : e199-200. 

[4] Morse, N. L., & Clough, P. M. (2006). Une méta-analyse des essais cliniques randomisés, contrôlés par placebo, de l'huile d'onagre dans l'eczéma atopique. [Kruger MC, Coetzer H, et al. "Gamma-linolenic acid and eicosapentaenoic acid in senile osteoporosis". Aging (Milano) 1998 Oct;10(5):385-94. 

[6] Cameron M & al. La phytothérapie pour le traitement de la polyarthrite rhumatoïde. Cochrane Database Syst Rev 2011 Feb 16;2:CD002948. 

[7] Laposata, M. (1996). " Traitement de la polyarthrite rhumatoïde par l'acide gamma-linolénique ". Une étude randomisée contrôlée par placebo". 

[8] "The effect of a medical diet containing gamma-linolenic acid and eicosapentaenoic acid on asthma management and quality of life in adult asthmatics". Curr Med Res Opin. 2008 ; 24(2) : 559-67. 

[9] "Effet de l'extrait de Borago Officinalis sur l'asthme persistant modéré : un essai clinique de phase deux, randomisé, en double aveugle, contrôlé par placebo".