Balance of the microbiota

Food supplement based on 10 strains of lactic ferments, non-irritating prebiotics (baobab pulp) and zinc citrate*.

This food supplement helps to :

• maintain the proper functioning of the microbiota
• maintain the proper functioning of the immune system*.

This food supplement contains 60 billion CFU/capsule including :

• Lactobacillus rhamnosus
• Lactobacillus johnsonii
• Lactobacillus casei
• Lactobacillus acidophilus
• Lactobacillus reuteri
• Lactobacillus plantarum
• Bifidobacterium bifidum
• Bifidobacterium lactis
• Bifidobacterium breve
• Bifidobacterium longum 

The ingredients in biotippin are protected by DRCAPS gastro-resistant capsules.

This innovative formula contains 10 strains of probiotics (60 billion CFU/capsule) combined with prebiotics from organic farming & zinc citrate which contribute to the proliferation of lactic ferments.

Scientific studies on probiotics

The lactobacilli and bifidobacteria have been carefully selected to rebalance the intestinal microbiota. Each strain has specific documented actions: "Bifidobacterium bifidum" effectively alleviates global IBS (irritable bowel syndrome)[1]; "Lactobacillus reuteri" regulates intestinal transit in children (diarrhoea)[2] and adults (chronic constipation)[3]; "Bifidobacterium breve" demonstrates, among other things, its antibacterial effectiveness against clostridium by inhibiting growth and eliminating spores[4]. Several randomised studies have demonstrated the ability of "Bifidobacteria" to decrease the level of several cytokines involved in systemic inflammation (interleukins 2-10), but also to improve the phagocytic capacity and the activity of natural killer cells[5]. The selected probiotics have immunoregulatory effects on IgA and CD4 expression (immune responses of IM) after exposure to Escherichia coli and lipopolysaccharide (LPS)[6]. 

Innovative synbiotic synergy

This synbiotic formula is manufactured in gastro-resistant capsules (DRcaps)[7] which protect the probiotics from gastric acidity to ensure that the strains are released in the small intestine.  

Nutritional information

* Reference Inputs / ** CFU: Colony Forming Unit 

Studies

[1] S Guglielmetti, D Mora, etc.; «Essai clinique randomisé: Bifidobacterium bifidum MIMBb75 atténue de manière significative le syndrome du côlon irritable et améliore la qualité de vie - une étude en double aveugle contrôlée par placebo»; Aliment Pharmacol Ther. 2011 May;33(10):1123-32. 

[2] M Kołodziej, H Szajewska, etc.; «Lactobacillus reuteri dans la prévention de la diarrhée associée aux antibiotiques chez les enfants: un essai clinique randomisé»; Clin Microbiol Infect. 2019 Jun;25(6):699-704. 

[3] Veronica Ojetti, Gianluca Ianiro, etc.; «L’effet de la supplémentation en Lactobacillus reuteri chez les adultes atteints de constipation fonctionnelle chronique: un essai randomisé, en double aveugle et contrôlé par placebo»; J Gastrointestin Liver Dis. 2014 Dec;23(4):387-91. 

[4] Jingpeng Yang, Hong Yang, etc.; «Activité antibactérienne de Bifidobacterium breve contre Clostridioides difficile»; Front Cell Infect Microbiol. 2019 Aug 7;9:288. 

[5] Ouwehand A.C., Bergsma N., etc.; « Les Bifidobactéries et les paramètres de la fonction immunitaire chez les sujets âgés. FEMS Immunol. Front Cell Infect Microbiol. 2019 Aug 7;9:288. 

[6] Alpha Fardah Athiyyah, Nur Aisiyah Widjaja, etc.; «Effets d’un synbiotique multispécifique sur les réponses immunitaires de la muqueuse intestinale»; Iran J Microbiol. 2019 Aug;11(4):300-304. 

[7] Capsugel’s Scintigraphic in vivo study of DRCAPS [https://www.capsugel.com/news/capsugels-scintigraphic-in-vivo-study-of-drcapstm-capsules-visually-tracks-].