Bone strength

Osteovits is a food supplement based on vitamins D3 and K2 combined with magnesium and zinc which contribute to the maintenance of normal bones. The addition of calcium is necessary for the maintenance of normal bone structure. Vitamin C contributes to the normal formation of collagen for normal bone function. Vitamin B6 contributes to normal protein metabolism.

Supplies the body with vitamins:

• Vitamin B6 
• Vitamin C
• vitamin D 
• Vitamin K

Supplies the body with citrate minerals:

• Calcium
• Magnesium
• Zinc

Osteovits is a nutritional supplement formulated for the maintenance of normal bone structure. Selected citrate minerals (bioavailable alkaline salts) such as calcium, magnesium and zinc, help to combat metabolic acidosis leading to bone demineralisation and low-grade inflammation.

Zinc is involved, among other things, in the synthesis of osteoblasts forming the bone matrix; magnesium slows down the rise in PTH (parathormone) in the event of stress (bone decalcification). A large proportion of the total magnesium is found in the bone (60%) and helps to modulate the formation of hydroxyapatite crystals. Magnesium regulates calcium transport and improves its binding [1]. Bone mineral density is dependent on calcium. Vitamins D and K optimise the formula by fixing calcium in the bone matrix.

Calcitriol also plays an important role in osteoblast differentiation and in the regulation of osteoclastogenesis and osteoclast activity [2]. Vitamin K activates the carboxylation of osteocalcin, allowing this protein to bind calcium to the bone framework and prevent peripheral calcification [3-4-5]. According to numerous studies, the menaquinone form (MK-7) is involved in reducing the risk of fracture in osteopenia [6-7].

Vitamin B6 catalyses lysyl oxidase, which facilitates the binding of collagen and protein fibres in the bone structure.

Finally, vitamin C is involved in the production of hydroxyproline (hydroxylation of proline) which is an integral part of endogenous collagen. According to this study[8] aimed at improving the organic composition of bone, vitamin supplementation (C and B6), combined with calcium supplementation, prevented bone loss in osteopenic subjects. Vitamin C participates with vitamins D and K in protecting bone and muscle tissue from inflammation.

Nutritional information

*  Reference intakes

[1] Stendig-Lindberg G et al. "Densité osseuse trabéculaire dans un essai contrôlé de deux ans de magnésium peroral dans l'ostéoporose", Magnes Res. 1993 juin; 6 (2): 155-63.

[2] Anderson PH et al. "Les effets pléiotropes de la vitamine D dans les os." J Steroid Biochem Mol Biol. 5 sept. 2012 doi: pii: S0960-0760 (12) 00151-3. 10.1016 / j.jsbmb.2012.08.008.

[3] Shea MK, Holden RM. Vitamin K status and vascular calcification: evidence from observational and clinical studies. Adv Nutr. 2012 Mar 1;3(2):158-65.

[4] Katarzyna Maresz, "Utilisation appropriée du calcium: la vitamine K2 comme promoteur de la santé osseuse et cardiovasculaire",  Integr Med (Encinitas) 2015 Feb;14(1):34-9.

[5] Julia Khéde Dourado Villa et al. "Effet de la vitamine K sur le métabolisme osseux et la calcification vasculaire: un examen des mécanismes d'action et des preuves", Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3959-3970.

[6] Cockayne S, Adamson J, LanhamNew S, Shearer MJ, Gilbody S, Torgerson DJ. La vitamine K et la prévention des fractures: revue systématique et méta-analyse d'essais contrôlés randomisés. Arch Intern Med. 26 juin 2006; 166 (12): 1256-61.;

[7] Dalmeije et al. "L'effet de la supplémentation en ménaquinone-7 sur les espèces circulantes de protéine de matrice Gla" Atherosclerosis. 2012 Dec;225(2):397-402.

[8] Massé PG, Jougleux JL, Dosy J et al. Effet du supplément OsCalD® combiné aux vitamines C et B6 sur la densité osseuse, le renouvellement et le métabolisme chez les femmes ostéopéniques d'âge moyen. FASEB J 2005; 19 (4): A56.